The show is a parody of hospital dramas such as "Grey's Anatomy" and "Scrubs." Corddry's show is actually filmed on the same sets as the latter show, a fact that one of the character's references in one episode, an example of the show's meta-humor. The show is about a group of doctors and nurses, most of whom have slept with one another, a parody of the many relationships doctors have in melodramatic hospital dramas. Characters include Blake Downs, a clown doctor who believes in the healing power of laughter, The Chief, the head of the hospital who is part Cherokee, which explains her name, and Sy, a hospital administrator played by Henry "The Fonz" Winkler. The show has great guest stars, including Jon Hamm, Ed Begley Jr., Nick Offerman, and Michael Cera as the voice of the PA system.
Together, the team of doctors face challenges like quicksand, amnesia viruses, Death (played by Michael McKean), criminally insane children, heat waves prompting a "Do the Right Thing" parody, crampt living situations, cancer guns, and Big Pharma. The show also messes around with format; one episode is a fake-live episode, while another one takes place in the 1970s.
Most of the jokes are throwaway lines, such as "Time of death: 9pm, 8 Central." It's hard to describe, so here's a clip, but it doesn't really do the show justice.